Multifunctional multi-shank neural probe for investigating and modulating long-range neural circuits in vivo.

ABSTRACT: Investigation and modulation of neural circuits in vivo at the cellular level are very important for studying functional connectivity in a brain. Recently, neural probes with stimulation capabilities have been introduced, and they provided an opportunity for studying neural activities at a specific region in the brain using various stimuli. However, previous methods have a limitation in dissecting long-range neural circuits due to inherent limitations on their designs. Moreover, the large size of the previously reported probes induces more significant tissue damage. Herein, we present a multifunctional multi-shank MEMS neural probe that is monolithically integrated with an optical waveguide for optical stimulation, microfluidic channels for drug delivery, and microelectrode arrays for reco

SUBMITTER: Shin H 

PROVIDER: S-EPMC6706395 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature