A Ca²⁺/CaM-regulated transcriptional switch modulates stomatal development in response to water deficit.

ABSTRACT: Calcium (Ca²⁺) signals are decoded by the Ca²⁺-sensor protein calmodulin (CaM) and are transduced to Ca²⁺/CaM-binding transcription factors to directly regulate gene expression necessary for acclimation responses in plants. The molecular mechanisms of Ca²⁺/CaM signal transduction processes and their functional significance remains enigmatic. Here we report a novel Ca²⁺/CaM signal transduction mechanism that allosterically regulates DNA-binding activity of GT2-LIKE 1 (GTL1), a transrepressor of STOMATAL DENSITY AND DISTRIBUTION 1 (SDD1), to repress stomatal development in response to water stress. We demonstrated that Ca²⁺/CaM interaction with the 2^nd helix of the GTL1 N-terminal trihelix DNA-binding domain (GTL1N)

SUBMITTER: Yoo CY 

PROVIDER: S-EPMC6706580 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature