Ontology highlight
ABSTRACT:
SUBMITTER: Aghaeepoor M
PROVIDER: S-EPMC6706719 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Iranian journal of pharmaceutical research : IJPR 20190101 2
Streptokinase (SK) is an extracellular protein comprising 414 amino acids with considerable clinical importance as a commonly used thrombolytic agent. Due to its wide spread application and clinical importance designing more efficient SK production platforms worth investigation. In this regard, a synthetic SK gene was optimized and cloned in to pET21b plasmid for periplasmic expression. Response surface methodology was used to design a total of 20 experiments for optimization of IPTG concentrati ...[more]