Association of Cortisol Levels With Neuropsychiatric Functions: A Mendelian Randomization Analysis.

ABSTRACT: Aim: The conflicting evidence as to whether a real association exists between cortisol levels and depression lends support to adopting a Mendelian randomization approach to investigate whether cortisol levels have a causal effect with depression. Methods: Single nucleotide polymorphisms (SNPs) associated with serum morning plasma cortisol level and salivary cortisol level from CORNET consortium (12,597 participants) were proposed as instrumental variables. The primary outcome was depression, and the secondary outcomes were neuroticism and cognitive performance. Summary-level statistics were extracted from the Social Science Genetic Association Consortium including the United Kingdom Biobank cohort (105,739 subjects). Multiple analysis methods (inverse-variance weighted method

SUBMITTER: Zhou X 

PROVIDER: S-EPMC6706785 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature