Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases.

ABSTRACT: Schizophrenia (SCZ) is a chronic debilitating neuropsychiatric disorder with multiple risk factors involving numerous complex genetic influences. We examined and updated a master list of clinically relevant and susceptibility genes associated with SCZ reported in the literature and genomic databases dedicated to gene discovery for characterization of SCZ genes. We used the commercially available GeneAnalytics computer-based gene analysis program and integrated genomic databases to create a molecular profile of the updated list of 608 SCZ genes to model their impact in select categories (tissues and cells, diseases, pathways, biological processes, molecular functions, phenotypes and compounds) using specialized GeneAnalytics algorithms. Genes for schizophrenia were predominantly expressed i

SUBMITTER: Sundararajan T 

PROVIDER: S-EPMC6706854 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature