The reduction of XIAP is associated with inflammasome activation in RPE: implications for AMD pathogenesis.

ABSTRACT:

Background

Age-related macular degeneration (AMD) is a multifactorial chronic disease of the eye. Several candidate pathways have been hypothesized to play a role in AMD pathogenesis. Our work and those of others suggests inflammasome activity as a mechanism associated with retinal pigment epithelial (RPE) cell demise. X-linked inhibitor of apoptosis protein (XIAP), an anti-apoptosis factor, has recently been shown to regulate inflammasome activity in non-ocular cells. The purpose of this study is to characterize XIAP's regulatory role in RPE.

Methods

Protein lysates of eye tissues from rats (vinpocetine- or aurin tricarboxylic acid complex-treated, ATAC, vs naïve) and mice (wild type vs Caspase-4^-/-) were utilized to analyze XIAP protein levels. Immunohistochemis

SUBMITTER: Gao J 

PROVIDER: S-EPMC6706877 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature