Replicated methylation changes associated with eczema herpeticum and allergic response.

ABSTRACT:

Background

Although epigenetic mechanisms are important risk factors for allergic disease, few studies have evaluated DNA methylation differences associated with atopic dermatitis (AD), and none has focused on AD with eczema herpeticum (ADEH+). We will determine how methylation varies in AD individuals with/without EH and associated traits. We modeled differences in genome-wide DNA methylation in whole blood cells from 90 ADEH+, 83 ADEH-, and 84 non-atopic, healthy control subjects, replicating in 36 ADEH+, 53 ADEH-, and 55 non-atopic healthy control subjects. We adjusted for cell-type composition in our models and used genome-wide and candidate-gene approaches.

Results

We replicated one CpG which was significantly differentially methylated by severity, with suggestive repli

SUBMITTER: Boorgula MP 

PROVIDER: S-EPMC6706929 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature