Persistent C-peptide secretion in Type 1 diabetes and its relationship to the genetic architecture of diabetes.

ABSTRACT:

Background

The objective of this cross-sectional study was to explore the relationship of detectable C-peptide secretion in type 1 diabetes to clinical features and to the genetic architecture of diabetes.

Methods

C-peptide was measured in an untimed serum sample in the SDRNT1BIO cohort of 6076 Scottish people with clinically diagnosed type 1 diabetes or latent autoimmune diabetes of adulthood. Risk scores at loci previously associated with type 1 and type 2 diabetes were calculated from publicly available summary statistics.

Results

Prevalence of detectable C-peptide varied from 19% in those with onset before age 15 and duration greater than 15 years to 92% in those with onset after age 35 and duration less than 5 years. Twenty-nine percent of variance in C-peptide l

SUBMITTER: McKeigue PM 

PROVIDER: S-EPMC6706940 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature