Association of a Primary Open-Angle Glaucoma Genetic Risk Score With Earlier Age at Diagnosis.

ABSTRACT:

Importance

Genetic variants associated with primary open-angle glaucoma (POAG) are known to influence disease risk. However, the clinical effect of associated variants individually or in aggregate is not known. Genetic risk scores (GRS) examine the cumulative genetic load by combining individual genetic variants into a single measure, which is assumed to have a larger effect and increased power to detect relevant disease-related associations.

Objective

To investigate if a GRS that comprised 12 POAG genetic risk variants is associated with age at disease diagnosis.

Design, setting, and participants

A cross-sectional study included individuals with POAG and controls from the Glaucoma Genes and Environment (GLAUGEN) study and the National Eye Institute Glaucoma Human Gen

SUBMITTER: Fan BJ 

PROVIDER: S-EPMC6707005 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature