Association of Plasma Amylin Concentration With Alzheimer Disease and Brain Structure in Older Adults.

ABSTRACT:

Importance

Preclinical studies suggest that amylin has a U-shaped dose-response association with risk of Alzheimer disease (AD). The association of plasma amylin with AD in humans is unknown.

Objectives

To measure amylin concentration in plasma by using enzyme-linked immunosorbent assay and to study the association between plasma amylin, incidence of AD, and brain structure in humans.

Design, setting, and participants

This cohort study used data from the Framingham Heart Study offspring cohort from 1998 to 2015. Using a Monte Carlo approach, participants were divided into 3 plasma amylin concentration groups: (1) low (<75 pmol/L), (2) high (75-2800 pmol/L), and (3) extremely high (≥2800 pmol/L). Data analyses were conducted October 5, 2017, to December 18, 2018.

Ex

SUBMITTER: Zhu H 

PROVIDER: S-EPMC6707010 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature