IL-4 Mediated Resistance of BALB/c Mice to Visceral Leishmaniasis Is Independent of IL-4Rα Signaling via T Cells.

ABSTRACT: Previous studies infecting global IL-4Rα^-/-, IL-4^-/-, and IL-13^-/-mice on a BALB/c background with the visceralizing parasite Leishmania donovani have shown that the T helper 2 cytokines, IL-4, and IL-13, play influential but not completely overlapping roles in controlling primary infection. Subsequently, using macrophage/neutrophil-specific IL-4Rα deficient BALB/c mice, we demonstrated that macrophage/neutrophil unresponsiveness to IL-4 and IL-13 did not have a detrimental effect during L. donovani infection. Here we expand on these findings and show that CD4⁺ T cell-(Lck^cre), as well as pan T cell-(iLck^cre) specific IL-4Rα deficient mice, on a BALB/c background, unlike global IL-4Rα deficient mice, are also n

SUBMITTER: McFarlane E 

PROVIDER: S-EPMC6707061 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature