Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice.

ABSTRACT: Increasing evidence point to the relevance of intestinal disfunction and changes in the microbiome composition during chronic liver disease. More specifically, recent studies have highlighted that cholestatic diseases associate with a reduction in the microbiome diversity in patients. Still, the dynamics of the changes in the microbiome composition observed, as well as their implication in contributing to the pathogenesis of this disease remain largely undefined. Hence, experimental mouse models resembling the human pathogenesis are crucial to move forward our understanding on the mechanisms underpinning cholestatic disease and to enable the development of effective therapeutics. Our results show that the bile duct ligation (BDL) experimental model of cholestasis leads to rapid and signifi

SUBMITTER: Cabrera-Rubio R 

PROVIDER: S-EPMC6707139 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature