Glia-neuron interactions underlie state transitions to generalized seizures.

ABSTRACT: Brain activity and connectivity alter drastically during epileptic seizures. The brain networks shift from a balanced resting state to a hyperactive and hypersynchronous state. It is, however, less clear which mechanisms underlie the state transitions. By studying neural and glial activity in zebrafish models of epileptic seizures, we observe striking differences between these networks. During the preictal period, neurons display a small increase in synchronous activity only locally, while the gap-junction-coupled glial network was highly active and strongly synchronized across large distances. The transition from a preictal state to a generalized seizure leads to an abrupt increase in neural activity and connectivity, which is accompanied by a strong alteration in glia-neuron interactions

SUBMITTER: Diaz Verdugo C 

PROVIDER: S-EPMC6707163 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature