Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis.

ABSTRACT: Aerobic exercise prevents age-dependent decline in cognition and hippocampal neurogenesis. The transcription factor peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) mediates many of the exercise-induced benefits in skeletal muscle, including the release of factors into the circulation with neurotrophic effects. We use a transgenic mouse model with muscle-specific overexpression of PGC-1α to study the contribution of chronic muscle activation on exercise-induced effects on hippocampal neurogenesis in aging. Young and old transgenic and wild type animals of both sexes displayed a robust age-related reduction in newborn BrdU⁺-cells, immature neurons (DCX⁺-cells) and new mature BrdU⁺/NeuN⁺-neurons in the dentate gyrus. N

SUBMITTER: Karlsson L 

PROVIDER: S-EPMC6707251 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature