Photocatalytic enantioselective α-aminoalkylation of acyclic imine derivatives by a chiral copper catalyst.

ABSTRACT: Copper-based asymmetric photocatalysis has great potential in the development of green synthetic approaches to chiral molecules. However, there are several formidable challenges associated with such a conception. These include the relatively weak visible light absorption, short excited-state lifetimes, incompatibility of different catalytic cycles, and the difficulty of the stereocontrol. We report here an effective strategy by means of single-electron-transfer (SET) initiated formation of radicals and photoactive intermediates to address the long-standing problems. Through elaborate selection of well-matched reaction partners, the chiral bisoxazoline copper catalyst is engaged in the SET process, photoredox catalysis, Lewis acid activation and asymmetric induction. Accordingly, a highly e

SUBMITTER: Han B 

PROVIDER: S-EPMC6707287 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature