Investigating safety profiles of human papillomavirus vaccine across group differences using VAERS data and MedDRA.

ABSTRACT:

Background

The safety of vaccines is a critical factor in maintaining public trust in national vaccination programs. This study aimed to evaluate the safety profiles of human papillomavirus (HPV) vaccines with regard to the distribution of adverse events (AE) across gender and age, and the correlations across various AEs using the Food and Drug Administration/Centers for Disease Control and Prevention Vaccine Adverse Event Reporting System (VAERS).

Methods

For analyses, 27,348 patients aged between 9 and 25 years old with at least one AE reported in VAERS between the year of 2006 and 2017 were included. AEs were summarized into two levels: the lower level preferred term (PT) and higher level system organ classes (SOCs) based on the structure of Medical Dictionary for Regulat

SUBMITTER: Jia Y 

PROVIDER: S-EPMC6707342 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature