Long noncoding RNA THAP9-AS1 is induced by Helicobacter pylori and promotes cell growth and migration of gastric cancer.

ABSTRACT:

Background

Long noncoding RNAs (LncRNAs) have been confirmed to play crucial roles in cancer biology. Gastric cancer (GC) is the third leading cause of cancer related death, and Helicobacter pylori (H. pylori) is the major risk factor for GC. In this study, we focused on the roles of H. pylori-related lncRNAs in the progression of GC.

Method

Differentially expressed lncRNAs were identified through RNA-seq analysis of H. pylori-infected GC cells.

Results

We found that the expression of the lncRNA THAP9-AS1 was up-regulated after infection of GC cells with H. pylori and was higher in GC tissues than in gastritis tissues. Colony formation, CCK8 and transwell assays were executed to show that THAP9-AS1 can promote GC cell proliferation a

SUBMITTER: Jia W 

PROVIDER: S-EPMC6707351 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature