Effects of Deuteration of ¹³C-Enriched Phospholactate on Efficiency of Parahydrogen-Induced Polarization by Magnetic Field Cycling.

ABSTRACT: We report herein a large-scale (>10 g) synthesis of isotopically enriched 1-¹³C-phosphoenolpyruvate and 1-¹³C-phosphoenolpyruvate-d₂ for application in hyperpolarized imaging technology. The 1-¹³C-phosphoenolpyruvate-d₂ was synthesized with 57% overall yield (over two steps), and >98% ²H isotopic purity, representing an improvement over the previous report. The same outcome was achieved for 1-¹³C-phosphoenolpyruvate. These two unsaturated compounds with C=C bonds were employed for parahydrogen-induced polarization via pairwise parahydrogen addition in aqueous medium. We find that deuteration of 1-¹³C-phosphoenolpyruvate resulted in overall increase of ¹H T₁ of nascent hyperpolarize

SUBMITTER: Salnikov OG 

PROVIDER: S-EPMC6707357 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature