CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape.

ABSTRACT: Chimeric antigen receptors (CARs) are synthetic antigen receptors that reprogram T cell specificity, function and persistence¹. Patient-derived CAR T cells have demonstrated remarkable efficacy against a range of B-cell malignancies^1-3, and the results of early clinical trials suggest activity in multiple myeloma⁴. Despite high complete response rates, relapses occur in a large fraction of patients; some of these are antigen-negative and others are antigen-low^1,2,4-9. Unlike the mechanisms that result in complete and permanent antigen loss^6,8,9, those that lead to escape of antigen-low tumours remain unclear. Here, using mouse models of leukaemia, we show that CARs provoke reversible antigen loss through trogocytosis, an active process

SUBMITTER: Hamieh M 

PROVIDER: S-EPMC6707377 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature