Differences Between the Raw Material and the Products of de Novo Gene Birth Can Result from Mutational Biases.

ABSTRACT: Proteins are among the most important constituents of biological systems. Because all protein-coding genes have a noncoding ancestral form, the properties of noncoding sequences and how they shape the birth of novel proteins may influence the structure and function of all proteins. Differences between the properties of young proteins and random expectations from noncoding sequences have previously been interpreted as the result of natural selection. However, interpreting such deviations requires a yet-unattained understanding of the raw material of de novo gene birth and its relation to novel functional proteins. We mathematically show that the average properties and selective filtering of the "junk" polypeptides of which this raw material is composed are not the only factors influe

SUBMITTER: Nielly-Thibault L 

PROVIDER: S-EPMC6707459 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature