HaploBlocker: Creation of Subgroup-Specific Haplotype Blocks and Libraries.

ABSTRACT: The concept of haplotype blocks has been shown to be useful in genetics. Fields of application range from the detection of regions under positive selection to statistical methods that make use of dimension reduction. We propose a novel approach ("HaploBlocker") for defining and inferring haplotype blocks that focuses on linkage instead of the commonly used population-wide measures of linkage disequilibrium. We define a haplotype block as a sequence of genetic markers that has a predefined minimum frequency in the population, and only haplotypes with a similar sequence of markers are considered to carry that block, effectively screening a dataset for group-wise identity-by-descent. From these haplotype blocks, we construct a haplotype library that represents a large proportion of genetic va

SUBMITTER: Pook T 

PROVIDER: S-EPMC6707469 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature