A biologically based mathematical model for spontaneous and ionizing radiation cataractogenesis.

ABSTRACT: Cataracts have long been known, but a biomathematical model is still unavailable for cataratogenesis. There has been a renewed interest in ionizing radiation cataracts because the recent international recommendation of the reduced lens dose limit stimulated the discussion toward its regulatory implementation in various countries. Nevertheless, a relationship between radiation (dose and dose rate) and response (e.g., incidence, onset and progression) remains incompletely understood, raising the need for a risk-predictive mathematical model. We here report for the first time an in silico model for cataractogenesis. First, a simplified cell proliferation model was developed for human lens growth based on stem and progenitor cell proliferation as well as epithelial-fiber cell differentiation.

SUBMITTER: Sakashita T 

PROVIDER: S-EPMC6707595 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature