Glucocorticoids for acute urticaria: study protocol for a double-blind non-inferiority randomised controlled trial.

ABSTRACT:

Introduction

This study protocol describes a trial designed to investigate whether antihistamine alone in patients with acute urticaria does not increase the 7-day Urticaria Activity Score (UAS7) in comparison with an association of antihistamine and glucocorticoids and reduces short-term relapses and chronic-induced urticaria.

Methods and analysis

This is a prospective, double-blind, parallel-group, multicentre non-inferiority randomised controlled trial. Two-hundred and forty patients with acute urticaria admitted to emergency department will be randomised in a 1:1 ratio to receive levocetirizine or an association of levocetirizine and prednisone. Randomisation will be stratified by centre. The primary outcome will be the UAS7 at day 7. The secondary outcomes will encompas

SUBMITTER: Javaud N 

PROVIDER: S-EPMC6707704 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature