Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T.

ABSTRACT: Studying the human subcortical auditory system non-invasively is challenging due to its small, densely packed structures deep within the brain. Additionally, the elaborate three-dimensional (3-D) structure of the system can be difficult to understand based on currently available 2-D schematics and animal models. Wfe addressed these issues using a combination of histological data, post mortem magnetic resonance imaging (MRI), and in vivo MRI at 7 Tesla. We created anatomical atlases based on state-of-the-art human histology (BigBrain) and postmortem MRI (50 µm). We measured functional MRI (fMRI) responses to natural sounds and demonstrate that the functional localization of subcortical structures is reliable within individual participants who were scanned in two different experiments. Furth

SUBMITTER: Sitek KR 

PROVIDER: S-EPMC6707786 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature