Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP.

ABSTRACT: The Plasmodium vivax Duffy-binding protein (DBP) is a prime target of the protective immune response and a promising vaccine candidate for P. vivax malaria. Naturally acquired immunity (NAI) protects against malaria in adults residing in infection-endemic regions, and the passive transfer of malarial immunity confers protection. A vaccine that replicates NAI will effectively prevent disease. Here, we report the structures of DBP region II in complex with human-derived, neutralizing monoclonal antibodies obtained from an individual in a malaria-endemic area with NAI. We identified protective epitopes using X-ray crystallography, hydrogen-deuterium exchange mass spectrometry, mutational mapping and P. vivax invasion studies. These approaches reveal that naturally acquired human antibodies ne

SUBMITTER: Urusova D 

PROVIDER: S-EPMC6707876 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature