Ontology highlight
ABSTRACT:
SUBMITTER: Durai V
PROVIDER: S-EPMC6707878 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature immunology 20190812 9
Induction of the transcription factor Irf8 in the common dendritic cell progenitor (CDP) is required for classical type 1 dendritic cell (cDC1) fate specification, but the mechanisms controlling this induction are unclear. In the present study Irf8 enhancers were identified via chromatin profiling of dendritic cells and CRISPR/Cas9 genome editing was used to assess their roles in Irf8 regulation. An enhancer 32 kilobases (kb) downstream of the Irf8 transcriptional start site (+32-kb Irf8) that w ...[more]