Regulation of waaH by PhoB during P_i Starvation Promotes Biofilm Formation by Escherichia coli O157:H7.

ABSTRACT: In open environments such as water, enterohemorrhagic Escherichia coli O157:H7 responds to inorganic phosphate (P_i) starvation by inducing the Pho regulon controlled by PhoB. This activates the phosphate-specific transport (Pst) system that contains a high-affinity P_i transporter. In the Δpst mutant, PhoB is constitutively activated and regulates the expression of genes in the Pho regulon. Here, we show that P_i starvation and deletion of the pst system enhance E. coli O157:H7 biofilm formation. Among differentially expressed genes of EDL933 grown under P_i starvation conditions and in the Δpst mutant, we have found that a member of the PhoB regulon, waaH, predicted to encode a glycosyltransferase, was high

SUBMITTER: Vogeleer P 

PROVIDER: S-EPMC6707920 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature