Genome-wide DNA methylation profiling in ectopic and eutopic of endometrial tissues.

ABSTRACT: PURPOSE:Endometriosis is a gynecological disease that causes the uterine lining to appear in other organs outside the uterus. As DNA methylation has an important role in this disorder, its profiling can reveal new information to improve the diagnosis and treatment of endometriosis patients. METHODS:We conducted a genome-wide methylation profiling of ectopic and eutopic endometrial tissues from women with and without endometriosis using Infinium Human Methylation 450K BeadChip arrays. DNA methylation samples were collected from nine ectopic and nine eutopic endometrial tissues of endometriosis and six endometrial tissues of healthy controls. RESULTS:Correlation heatmaps and the principal component analysis divided the samples into two clusters, one consisting of all ectopic samples and the

SUBMITTER: Barjaste N 

PROVIDER: S-EPMC6708023 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature