Metabolomics for predicting hyperglycemia in pregnancy: a protocol for a systematic review and potential meta-analysis.

ABSTRACT:

Background

Hyperglycemia in pregnancy (HIP) has been recently differentiated between diabetes in pregnancy (DIP) and gestational diabetes mellitus (GDM). The proposed protocol is relevant, and clinical concern is due to the higher risk of adverse pregnancy outcomes (APO) and long-term effects on both the mother and the fetus. Fasting plasma glucose level (FPG) and oral glucose tolerance test (OGTT) are current diagnostic tools. However, controversy persists concerning diagnostic criteria, cut-off points, and even selective or universal screening. The objective of this systematic review is to assess the performance of metabolomic markers in the prediction of HIP.

Methods

This is a protocol for a systematic review with potential meta-analysis. The primary outcome is GDM, defin

SUBMITTER: Nicolosi BF 

PROVIDER: S-EPMC6708156 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature