Somatic maintenance impacts the evolution of mutation rate.

ABSTRACT:

Background

The evolution of multi-cellular animals has produced a conspicuous trend toward increased body size. This trend has introduced at least two novel problems: an expected elevated risk of somatic disorders, such as cancer, and declining evolvability due to generally reduced population size, lower reproduction rate and extended generation time. Low population size is widely recognized to explain the high mutation rates in animals by limiting the presumed universally negative selection acting on mutation rates.

Results

Here, we present evidence from stochastic modeling that the direction and strength of selection acting on mutation rates is highly dependent on the evolution of somatic maintenance, and thus longevity, which modulates the cost of somatic mutations.

Co

SUBMITTER: Rozhok A 

PROVIDER: S-EPMC6708161 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature