The impact on malaria of biannual treatment with azithromycin in children age less than 5 years: a prospective study.

ABSTRACT:

Background

The MORDOR study, a cluster randomized clinical trial, showed that single-dose azithromycin (20 mg/kg) administered biannually for 2 years to preschool children reduced mortality; a study was conducted to determine its effect on clinical symptomatic episodes of malaria as a potential mechanism for mortality benefit.

Methods

A randomized control trial (RCT) was conducted, whereby 30 randomly selected communities in Kilosa District, Tanzania were randomized to receive 6-monthly treatment of children ages 1-59 months with single-dose azithromycin (20 mg/kg) vs. placebo. A prospective cohort study was nested within the RCT: children, aged 1 to 35 months at baseline, were randomly selected in each community and evaluated at 6-monthly intervals for 2 years. At each visi

SUBMITTER: Bloch EM 

PROVIDER: S-EPMC6708241 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature