Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis.

ABSTRACT: Commensal bacteria influence host physiology, without invading host tissues. We show that proteins from segmented filamentous bacteria (SFB) are transferred into intestinal epithelial cells (IECs) through adhesion-directed endocytosis that is distinct from the clathrin-dependent endocytosis of invasive pathogens. This process transfers microbial cell wall-associated proteins, including an antigen that stimulates mucosal T helper 17 (T_H17) cell differentiation, into the cytosol of IECs in a cell division control protein 42 homolog (CDC42)-dependent manner. Removal of CDC42 activity in vivo led to disruption of endocytosis induced by SFB and decreased epithelial antigen acquisition, with consequent loss of mucosal T_H17 cells. Our findings demonstrate direct communicatio

SUBMITTER: Ladinsky MS 

PROVIDER: S-EPMC6708280 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature