Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination.

ABSTRACT: Understanding the mechanisms of vaccine-elicited protection contributes to the development of new vaccines. The emerging field of systems vaccinology provides detailed information on host responses to vaccination and has been successfully applied to study the molecular mechanisms of several vaccines. Long noncoding RNAs (lncRNAs) are crucially involved in multiple biological processes, but their role in vaccine-induced immunity has not been explored. We performed an analysis of over 2,000 blood transcriptome samples from 17 vaccine cohorts to identify lncRNAs potentially involved with antibody responses to influenza and yellow fever vaccines. We have created an online database where all results from this analysis can be accessed easily. We found that lncRNAs participate in distinct immunol

SUBMITTER: de Lima DS 

PROVIDER: S-EPMC6708379 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature