Programmed cell death 4 (PDCD4) as a novel prognostic marker for papillary thyroid carcinoma.

ABSTRACT:

Background

The primary goal of papillary thyroid cancer (PTC) management was to stratify patients at pre- and post-surgical level to identify the small proportion of cases with potentially aggressive disease.

Purpose

The aim of our study is to evaluate the possible role of programmed cell death 4 (PDCD4) and BRAF status as prognostic markers in PTC.

Patients and methods

We investigate programmed cell death 4 (PDCD4) immunohistochemical expression in 125 consecutive PTCs with median follow-up of 75.3 months (range, 15-98 months) to verify the possible correlation between BRAF status and correlate the classical clinicopathological prognostic factors and PTC outcome with PDCD4 expression. To further support the data, miR-21 expression was tested (by quantitative real-tim

SUBMITTER: Galuppini F 

PROVIDER: S-EPMC6708393 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature