Effects of Processing on a Sustained Release Formulation Prepared by Twin-Screw Dry Granulation.

ABSTRACT: Dry granulation is an indispensable process used to improve the flow property of moisture-sensitive materials. Considering the limitations of currently available dry granulation techniques, it is necessary to develop a novel technique. In this study, a twin-screw dry granulation (TSDG) technology was successfully applied to produce a sustained-release dry granule formulation, which was subsequently compressed into sustained-release tablets. Based on a preliminary study, theophylline was selected as model drug, Klucel^™ EF, Ethocel^™, and magnesium stearate were selected as excipients. A Resolution V Irregular Fraction Design was applied to determine the effect of different processing parameters (screw speed, feeding rate, barrel temperature, and screw configuration) on

SUBMITTER: Ye X 

PROVIDER: S-EPMC6708445 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature