Docosahexaenoic acid decreased neuroinflammation in rat pups after controlled cortical impact.

ABSTRACT: Traumatic brain injury (TBI) is the leading cause of acquired neurologic disability in children, yet specific therapies to treat TBI are lacking. Therapies that decrease the inflammatory response and enhance a reparative immune action may decrease oxidative damage and improve outcomes after TBI. Docosahexaenoic acid (DHA) modulates the immune response to injury in many organs. DHA given in the diet before injury decreased rat pup cognitive impairment, oxidative stress and white matter injury in our developmental TBI model using controlled cortical impact (CCI). Little is known about DHA effects on neuroinflammation in the developing brain. Further, it is not known if DHA given after developmental TBI exerts neuroprotective effects. We hypothesized that acute DHA treatment would decrease ox

SUBMITTER: Schober ME 

PROVIDER: S-EPMC6708465 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature