Oxidative metabolism alterations in the emotional brain of anxiety-prone rats.

ABSTRACT: Mood disorders such as anxiety and depression are heterogeneous disorders with many sufferers unresponsive to current pharmacological treatments. Individual differences in temperament represent one factor that may underlie symptom heterogeneity, so understanding its biological underpinnings can help pave the way to personalized therapies and improved patient outcomes. The present study uses a rodent model of temperamental differences to examine whether individual differences in emotional behavior phenotypes correspond to altered limbic brain cellular metabolism, an indicator of neuronal activity. The model uses two selectively bred rat lines - high novelty responder rats (HRs) that show highly exploratory behavior in a novel environment, active coping style and resilience to chronic mild s

SUBMITTER: McCoy CR 

PROVIDER: S-EPMC6708503 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature