Endometrium and endometriosis tissue mitochondrial energy metabolism in a nonhuman primate model.

ABSTRACT:

Background

Endometriosis is the growth of uterine lining (endometrium) outside of the uterus. In other chronic inflammatory diseases, mitochondrial dysfunction is suspected of playing a role in disease pathogenesis. However, little is known about endometriosis mitochondrial function or its effects on tissue metabolism. The objectives of this study were to analyze mitochondrial function in nonhuman primate (NHP) endometrium and endometriosis tissue and to identify the metabolic features of these tissues that may contribute to disease.

Methods

Mitochondrial function in endometriosis tissue and endometrium was measured using mitochondrial respirometry analysis to determine if changes in oxidative phosphorylation exist in endometrium and endometriosis tissue compared to control

SUBMITTER: Atkins HM 

PROVIDER: S-EPMC6708555 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature