Acute Demyelinating Events Following Vaccines: A Case-Centered Analysis.

ABSTRACT:

Background

 Case reports have suggested that vaccines may trigger transverse myelitis (TM) or acute disseminated encephalomyelitis (ADEM), but the evidence for a causal association is inconclusive. We analyzed the association of immunization and subsequent development of TM or ADEM.

Methods

 We identified all cases of TM and ADEM in the Vaccine Safety Datalink population. Using a case-centered method, we compared vaccination of each case to vaccination of all matched persons in the study population, who received the same type of vaccine, with respect to whether or not their vaccination occurred during a predetermined exposure interval. We calculated a risk difference (excess risk) of TM and ADEM for each vaccine.

Results

 Following nearly 64 million vaccine doses, onl

SUBMITTER: Baxter R 

PROVIDER: S-EPMC6708556 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature