Genetic Risk Score in Diabetes Associated With Chronic Pancreatitis Versus Type 2 Diabetes Mellitus.

ABSTRACT:

Introduction

Diabetes mellitus (DM) is a complication of chronic pancreatitis (CP). Whether pancreatogenic diabetes associated with CP-DM represents a discrete pathophysiologic entity from type 2 DM (T2DM) remains uncertain. Addressing this question is needed for development of specific measures to manage CP-DM. We approached this question from a unique standpoint, hypothesizing that if CP-DM and T2DM are separate disorders, they should be genetically distinct. To test this hypothesis, we sought to determine whether a genetic risk score (GRS) based on validated single nucleotide polymorphisms for T2DM could distinguish between groups with CP-DM and T2DM.

Methods

We used 60 T2DM single nucleotide polymorphisms to construct a weighted GRS in 1,613 subjects from the North Ameri

SUBMITTER: Goodarzi MO 

PROVIDER: S-EPMC6708663 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature