Blunted Evoked Prouroguanylin Endocrine Secretion in Chronic Constipation.

ABSTRACT:

Objectives

Prouroguanylin (ProUGN) in the intestine is cleaved to form uroguanylin (UGN), which stimulates guanylate cyclase C (GUCY2C), inducing cyclic guanosine monophosphate signaling. Paracrine release regulates fluid secretion, contributing to bowel function, whereas endocrine secretion evoked by eating forms a gut-brain axis, controlling appetite. Whereas hormone insufficiency contributes to hyperphagia in obesity, its contribution to the pathophysiology of constipation syndromes remains unexplored. Here, we compared circulating ProUGN and UGN in healthy subjects and in patients with chronic idiopathic constipation (CIC) and patients with irritable bowel syndrome with constipation (IBS-C).

Methods

Circulating ProUGN and UGN levels were measured in 60 healthy subjects,

SUBMITTER: Waldman SA 

PROVIDER: S-EPMC6708669 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature