Genetic polymorphisms and pancreatic cancer risk: A PRISMA-compliant systematic review and meta-analysis.

ABSTRACT:

Backgrounds

Previous investigations yielded inconsistent results for the associations between pancreatic cancer (PC) risk and genetic polymorphisms. The study aimed to perform a systematic review and meta-analysis of studies exploring association of some genetic polymorphisms and PC risk.

Methods

We systematically searched on PubMed and Web of Science for association of genetic polymorphisms and PC risk published from 1969 to January 2019. We computed the multivariate odd ratio (OR) and 95% confidence intervals (CI), comparing different genetic types.

Results

The present meta-analysis showed significant associations between deoxyribonucleic acid (DNA) repair gene (X-ray repair cross-complementing group 1 (XRCC1) Arg399GIn and Arg194Trp, excision repair cross complemen

SUBMITTER: Dai P 

PROVIDER: S-EPMC6708677 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature