Recurrence Risk of Autism in Siblings and Cousins: A Multinational, Population-Based Study.

ABSTRACT:

Objective

Familial recurrence risk is an important population-level measure of the combined genetic and shared familial liability of autism spectrum disorder (ASD). Objectives were to estimate ASD recurrence risk among siblings and cousins by varying degree of relatedness and by sex.

Method

This is a population-based cohort study of livebirths from 1998 to 2007 in California, Denmark, Finland, Israel, Sweden and Western Australia followed through 2011 to 2015. Subjects were monitored for an ASD diagnosis in their older siblings or cousins (exposure) and for their ASD diagnosis (outcome). The relative recurrence risk was estimated for different sibling and cousin pairs, for each site separately and combined, and by sex.

Results

During follow-up, 29,998 cases of ASD wer

SUBMITTER: Hansen SN 

PROVIDER: S-EPMC6708733 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature