A marijuana-drug interaction primer: Precipitants, pharmacology, and pharmacokinetics.

ABSTRACT: In the United States, the evolving landscape of state-legal marijuana use for recreational and/or medical purposes has given rise to flourishing markets for marijuana and derivative products. The popularity of these products highlights the relative absence of safety, pharmacokinetic, and drug interaction data for marijuana and its constituents, most notably the cannabinoids. This review articulates current issues surrounding marijuana terminology, taxonomy, and dosing; summarizes cannabinoid pharmacology and pharmacokinetics; and assesses the drug interaction risks associated with co-consuming marijuana with conventional medications. Existing pharmacokinetic data are currently insufficient to fully characterize potential drug interactions precipitated by marijuana constituents. As such, in

SUBMITTER: Cox EJ 

PROVIDER: S-EPMC6708768 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature