P300 as an index of transition to psychosis and of remission: Data from a clinical high risk for psychosis study and review of literature.

ABSTRACT: Auditory P300 oddball and novel components index working memory operations and salience processing, respectively, and are regarded as biomarkers of neurocognitive changes in both chronic and first-episode schizophrenia. Much less is known about whether P300 abnormalities exist in individuals at clinical high risk for psychosis (CHR) and if they are predictors of both transition to psychosis and remission from symptoms. One hundred and four CHR and 69 healthy control individuals (HC) completed P300 oddball paradigm, and 131 CHR and 69 HC subjects completed P300 novel paradigm. All CHR subjects were followed up for one year and stratified into CHR converters (CHRC) and non-converters (CHR-NC), with CHR-NC further stratified into remitted and non-remitted subgroups. Between-group comparisons

SUBMITTER: Tang Y 

PROVIDER: S-EPMC6708777 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature