Childhood obesity leads to adult type 2 diabetes and coronary artery diseases: A 2-sample mendelian randomization study.

ABSTRACT: Observational studies have reported that childhood obesity is positively associated with risks of type 2 diabetes (T2D) and coronary artery disease (CAD) in adults; however, whether this association is causal is still unclear. In the present study, we conducted the 2-sample Mendelian randomization (MR) studies to investigate whether childhood obesity is causally associated with T2D and CAD in adults.Seven single-nucleotide polymorphisms (SNPs) that significantly associated with childhood obesity were used as instrumental variables. The 2-sample MR analyses were performed with the summary-level data of large-sample genome-wide association studies to evaluate the causal effects of childhood obesity on adult T2D and CAD and the levels of cardiometabolic traits.The 2-sample MR analyses suggest

SUBMITTER: Fang X 

PROVIDER: S-EPMC6708873 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature