Biomarkers for detecting prostate cancer: Protocol for an umbrella review with integrated network meta-analysis.

ABSTRACT:

Background

Prostate cancer (PCa) is common, with it being the 2nd most prevalent cancer in men worldwide and the 6th leading cause of death in men. Screening for any type of cancer aims to increase the chances of successful treatment through early detection of the disease. There were some systematic reviews (SRs) evaluated the diagnostic value of biomarkers for the diagnosis of PCa and no studies have been conducted to analyze the quality of these SRs. We are not clear which kind of marker is the best choice. Thus, this study aims to assess the methodologic quality of the SRs and reanalyze the published data based on SRs for the biomarkers to find the optimal biomarker for the early diagnosis of PCa.

Methods

We performed a systematic literature search of PubMed, Embase, Web

SUBMITTER: Jia J 

PROVIDER: S-EPMC6708917 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature