Association between CYP1A1 rs4646903 T > C genetic variations and male infertility risk: A meta-analysis.

ABSTRACT:

Background

Number of studies have been performed to investigate the relationship between the CYP1A1 rs4646903 polymorphism and male infertility risk, but the sample size was small and the results were conflicting. A meta-analysis was performed to assess these associations.

Methods

A systematic search was conducted to identify all relevant studies from Medline, Web of science, Embase, China biology medical literature database (CBM), China National Knowledge Infrastructure (CNKI), WanFang and Weipu (VIP) databases up to June 30, 2018. The odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of associations. All of the statistical analyses were conducted using Revman 5.3 and Stata 14.0.

Results

Ten studies involved 3028 cases and 3

SUBMITTER: Cao D 

PROVIDER: S-EPMC6709244 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature