Plasmid-Mediated mcr-1 Colistin Resistance in Escherichia coli from a Black Kite in Russia.

ABSTRACT: The gene mcr-1 conferring resistance to last-line antibiotic colistin has been reported globally. Here, we describe the first detection of plasmid-mediated colistin resistance in Russian wildlife, an isolate of Escherichia coli sequence type 2280 from a black kite (Milvus migrans) scavenging raptor. Whole-genome sequencing and plasmid transferability experiments revealed that mcr-1.1 was located on conjugative IncI2 plasmid pDR164 (59891 bp). Migratory black kites may contribute to the global spread of mobile colistin resistance.

SUBMITTER: Tarabai H 

PROVIDER: S-EPMC6709458 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature