Ontology highlight
ABSTRACT:
SUBMITTER: Iida N
PROVIDER: S-EPMC6709532 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20131101 6161
The gut microbiota influences both local and systemic inflammation. Inflammation contributes to development, progression, and treatment of cancer, but it remains unclear whether commensal bacteria affect inflammation in the sterile tumor microenvironment. Here, we show that disruption of the microbiota impairs the response of subcutaneous tumors to CpG-oligonucleotide immunotherapy and platinum chemotherapy. In antibiotics-treated or germ-free mice, tumor-infiltrating myeloid-derived cells respo ...[more]